We have encountered many such cases, and it is usually related to antivirus software.
For example, with the built-in RAV Endpoint Protection on the computer, you can resume saving operations normally after disabling the real-time protection feature of these programs.
Of course, any corrupted save files must be deleted; otherwise, the game will keep freezing. Please delete them from the Save Folder (for example, .tmp files and their corresponding save files). Be sure to keep cloud saves turned off to avoid syncing corrupted files.
#If you can't find the save path, please refer to the following#:
The part "C:\Users" varies depending on your computer's user name, so we recommend locating the folder using the following method:
Open Windows File Explorer.
Copy and paste the following into the address bar: %userprofile%\AppData\LocalLow
Press Enter, and you should see a folder named "AtricGames."
Open the "SkyBrew_Entropic Strategist\Saves" folder.