There appears to be a bug with loading your game. It seems to be related to having a wand in your inventory. The character is loaded first but when the wand is put back into your inventory its number of charges is re-rolled, thus throwing off the RNG used for generating the level the way it was when you saved.
Expect this to be fixed and an update to be released either today or tomorrow.
Until then either try to finish your run or if you must save then use up the charges in your wand and throw it and hit an enemy with it to delete it from the level.
My sincere apologies - Jurax