Mass Effect 3 will introduce James Vega, a new character whose journey through the story is included to help newcomers understand the trilogy. The voice actor for Vega is this man, Fred from Scooby Doo. Zoinks!
OK, OK, he also has sci-fi/video game acting chops, as Lt. Blair in 1999's Wing Commander (a flop that made Scooby-Doo look like A Passage to India). Well, anyway, at least it's not Nolan North, right?
You can get Prinze's take on Vega and Mass Effect (he's played the first two games, he says) in this GameTrailers TV excerpt from yesterday.