A new start is strongly recommended. Old saves will work but it will give some errors when you load it. Such errors are not game-breaking though.
The real reason for a new start is implementation of three new characters as well as rebalance of existing characters.
So, here they are, the three romance options for Nick, fully finalized.

⨭ Added
1. Zone names (top left) is now far more specific. It’s been basically revamped.
2. Weapon shop added, finally. You can purchase grenades from there along with weapon upgrades.
3. Shops are now referred as its store name if it exists. For an example, the weapon store is called NekoNeko Arsenal.
4. Aurora is added. She is the second romance target for Nick and is the brain of the Kitty cats. Overall, she is upgraded Cass as both are ESPs. You cannot meet her yet but the character (sprite, bust images, etc) is implemented.
5. The heroine is introduced via a side quest “The fuck is happening?” Her real identity won’t be revealed for a while, but she is the third romance option for Nick. The heroine will mostly clash with Kleon and will sometimes be comic relief. She has the nicest body of all three (Cass and Aurora).
6. Some side quests now have timers. This is one of reasons for a new start as these will no longer advance with old saves.
7. Character rebalance:
⭷ Cass has been given more attack, making her pistol attack slightly more useful.
⭷ Waka drone (the first drone) has been slightly buffed.
⭷ Dakarai and Foluke have also been buffed.
8. Nick’s profile has been added under Extra.
💘 NSFW stuff
0. None in this patch.
↹ Changed
1. The new title screen was causing an issue when you start a new game. This is now fixed.
2. You can now stack up to 200 items each. 99 ammo max was too little.
