In the entire history of videogames, there have only been a few recorded cases of a studio performing the forbidden alchemy of transposing a game into another genre entirely. Until now, the most successful was probably R-Type Tactics (originally for the humble PSP, and now currently being remade), but I think the crown might have to go to Metal Slug Tactics...
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Metal Slug Tactics review
Source: PC Gamer (opens in a new tab)