There's a lot you can miss in Deathloop. It's spread across four regions, each with four time periods, and given the reactivity between these regions and time periods, it's possible to complete a playthrough without discovering heaps of stuff. It's been nearly a month since Arkane's latest release though, and it's fair to say that the internet's collective efforts have probably uncovered everything. Right?..
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Deathloop has at least one undiscovered secret left, says level designer
Source: PC Gamer (opens in a new tab)