I figured I was going to have to uninstall my Cyberpunk 2077 mods before checking out Phantom Liberty and update 2.0. Most of the mods I went for on my last playthrough were difficulty and loot adjustments that'd clash with 2.0's big changes, and for the rest, mod authors would likely need to update their files to play nice with the patch. What I wasn't expecting was needing to do a clean reinstall—complete with deleting some leftover files—to clear up a persistent crash on startup...
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You should delete your Cyberpunk 2077 mods ahead of update 2.0, and you may need to do a clean reinstall of the game
Source: PC Gamer (opens in a new tab)