I have released a fix to this problem.
The new relic - Amplifier Well, Upgrade Sockets - crash the game. Not instantly, but after you save and press "Start" on the main menu - so avoid installing this relic. If you already have Amplifier Well installed and saved in your save file, you have two options: 1) Wait for the update. 2) Erase save files with Amplifier Well, Upgrade Sockets. To do that, run Sector Six, then go to C:\Users\\AppData\Local\SectorSix, find the folder that contains your save files, and delete them, then close the game and start it again.It should look something like this Note: If you want to keep backup copies of your save files, don't keep them in SectorSix folder. I'm very sorry!